BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
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BACE2, a b-secretase homolog, cleaves at the b site and within the amyloid-b region of the amyloid-b precursor protein
Production of amyloid-b protein (Ab) is initiated by a b-secretase that cleaves the Ab precursor protein (APP) at the N terminus of Ab (the b site). A recently identified aspartyl protease, BACE, cleaves the b site and at residue 11 within the Ab region of APP. Here we show that BACE2, a BACE homolog, cleaves at the b site and more efficiently at a different site within Ab. The Flemish missense...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.160115697